Jump to content

Lysine dehydrogenase

From Wikipedia, the free encyclopedia
lysine dehydrogenase
Identifiers
EC no.1.4.1.15
CAS no.68073-29-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a lysine dehydrogenase (EC 1.4.1.15) is an enzyme that catalyzes the chemical reaction

L-lysine + NAD+ 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH + H+

Thus, the two substrates of this enzyme are L-lysine and NAD+, whereas its 4 products are 1,2-didehydropiperidine-2-carboxylate, NH3, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-lysine:NAD+ oxidoreductase (deaminating, cyclizing).

References

[edit]
  • Burgi W, Richterich R, Colombo JP (1966). "L-Lysine dehydrogenase deficiency in a patient with congenital lysine intolerance". Nature. 211 (5051): 854–5. doi:10.1038/211854a0. PMID 4291003.